Led by CEO Scott Adelson, Houlihan Lokey operates through three main business lines: corporate finance (comprising mergers and acquisitions, capital solutions, and board advisory services), financial restructuring, and financial and valuation advisory. The firm is headquartered in Los Angeles, and has additional offices in the Americas in Atlanta, Baltimore, Boston, Charlotte, Chicago, Dallas, Houston, Miami, Minneapolis, New York, San Francisco, São Paulo, and Washington, D.C. In all, it has 35 locations around the world, including overseas offices in Europe (Amsterdam, Antwerp, Frankfurt, London, Madrid, Manchester, Milan, Munich, Paris, Stockholm, Zurich); the Middle East (Dubai and Tel Aviv); and the Asia-Pacific region (Beijing, Gurugram, Hong Kong SAR, Mumbai, Shanghai, Singapore, Sydney, and Tokyo).

Over the past decade, the firm has made several acquisitions. Most recently, in December 2024, the firm acquired Waller Helms Advisors and Park Sutton Advisors, doubling the size of its Financial Services Group and substantially enhancing its coverage capabilities in the insurance and wealth management sectors.